Adult:
Modified-release preparation: Initially, 150 mg once daily increased to 150 mg bid after 3 days. Period of treatment: 7-12 wk. To discontinue treatment if abstinence is not achieved by 7th wk. Max: 300 mg/day. Elderly: 150 mg/day.
Oral
TREATMENT OF DEPRESSION
Adult:
Administration
May be taken with or without food.
Precautions
History of seizure disorders, bipolar disorders; MI or unstable heart disease; pregnancy; renal or hepatic impairment. Monitor BP before and after treatment; monitor wkly if used with nicotine products. May impair ability to drive and operate machinery. Avoid use within 2 wk of MAO inhibitor withdrawal.
Potentially Life-threatening
Adverse Drug Reactions
Concurrent use with MAO inhibitors may cause acute toxicity symptoms and increased risk of fatality.
Neuroleptics, lithium and TCAs, benzodiazepine, alcohol, drugs that lower seizure threshold. Increased risk of side effects when co-admin with levodopa. Reduced hepatic clearance with fluoxetine. Caution when administering with agents that will affect hepatic drug metabolizing enzymes. Increased risk of toxicity when used with ritonavir.
